We report an alternative synthesis of the two enantiomers of the floral fragrance Rosaphen. The key intermediate 2-methyl-5 phenylpentanoic acid 3 is synthesized via asymmetric hydrogenation (ee up to 99%) in the presence of an in situ prepared ruthenium catalyst containing the chiral ferrocenyl phosphine Mandyphos-4.

An Alternative Stereoselective Synthesis of (R)- and (S)-Rosaphenvia Asymmetric Catalytic Hydrogenation

MATTEOLI, Ugo;BEGHETTO, Valentina;SCRIVANTI, Alberto;AVERSA, MANUELA;BERTOLDINI, Matteo;
2011-01-01

Abstract

We report an alternative synthesis of the two enantiomers of the floral fragrance Rosaphen. The key intermediate 2-methyl-5 phenylpentanoic acid 3 is synthesized via asymmetric hydrogenation (ee up to 99%) in the presence of an in situ prepared ruthenium catalyst containing the chiral ferrocenyl phosphine Mandyphos-4.
2011
23
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10278/25880
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