Aliphatic and aromatic 1,4-bifunctional compounds bearing a primary alcoholic function and an amine can be efficiently cyclised with dimethyl carbonates in the presence of a base to achieve 5-membered N-heterocyclic compounds. This novel synthetic pathway is quantitative, one-pot and green as it does not involve the use of chlorine solvents or reagent.
|Titolo:||5-Membered N-heterocyclic compounds by dimethyl carbonate chemistry|
|Data di pubblicazione:||2012|
|Appare nelle tipologie:||2.1 Articolo su rivista |