At high temperature (1 80-200 "C) esters, orthoesters, carbonates and orthocarbonates have been found to alkylate acidic compounds via a B,,2 mechanism. Phenol gives anisole with methyl acetate in the presence of potassium carbonate. Thiols and other CH-acidic compounds are also alkylated under such conditions. The results obtained under batch conditions can be repeated under continuous-flow conditions, if the base which promotes the reaction can be used in catalytic amount. Continuous-flow alkylation of thiophenol by methyl acetate on a sodium acetate-type fixed bed, and other alkylations by orthoesters or orthocarbonates on a potassium carbonate catalytic bed, have been achieved.
|Data di pubblicazione:||1992|
|Titolo:||Esters and Orthoesters as Alkylating Agents at High Temperature. Applicationsto Continuous-flow Processes|
|Rivista:||JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS II|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1039/P29920000519|
|Appare nelle tipologie:||2.1 Articolo su rivista |