A series of titanium oxides was prepared by a surfactant template method (STM) and used as carrier to sustain the release of ibuprofen, chosen as model drug. The STM procedure provides an efficient method to prepare TiO2 matrices with both high surface area (if compared with those obtained with the traditional synthetic approach) and a well defined mesoporous texture. Some parameters of the synthetic procedure were varied: pH, surfactant and thermal treatment. The physico-chemical nature of the surface carriers were investigated by means of N2 physisorption measurements and FT-IR analyses. The effect of the drug amount on the release kinetic was also investigated. The drug delivery was evaluated in vitro in four different physiological solutions (simulating the gastro-intestinal tract) in order to analyze the behaviour of the TiO2-based systems if formulated as oral DDS. The optimized approach turns out to be a good alternative to the classical methods employed to prepare efficient TiO2-based drug delivery systems.
|Titolo:||Structure-Directing Agent for the Synthesis of TiO2-Based Drug Delivery Systems|
|Data di pubblicazione:||2012|
|Appare nelle tipologie:||2.1 Articolo su rivista |
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