A new catalytic synthesis of Cyclamen-aldehyde (3-(4-isopropylphenyl)-2-methylpropanal) has been developed. The devised synthetic approach entails as the key step the asymmetric hydrogenation of (E)-3-(4- isopropylphenyl)-2-methyl acrylic acid which has been carried out with ees of about 60% by using a catalytic system prepared by combining in situ [Ru(C6H6)Cl2]2 and (S)-MeO-BIPHEP.
|Titolo:||Asymmetric catalysis in fragrance chemistry: a new catalytic approach to non racemic Cyclamen-aldehyde|
|Data di pubblicazione:||2012|
|Appare nelle tipologie:||2.1 Articolo su rivista |