The mechanism of lignin nanoprecipitation and subsequent self-assembly was elucidated by studying generation of lignin nanoparticles (LNPs) from aqueous ethanol. LNP formation was found to follow a kinetically controlled nucleation-growth mechanism in which large lignin molecules formed the initial critical nuclei. Using this information, we demonstrate entrapment of budesonide in LNPs and subsequent pH-triggered and surfactant-responsive release of this synthetic anti-inflammatory corticosteroid. Overall, our results not only provide a promising intestinal delivery system for budesonide but also deliver fundamental mechanistic understanding for the entrapment of actives in LNPs with controlled size and release properties.
Crestini, Claudia (Corresponding)
|Data di pubblicazione:||2018|
|Titolo:||Understanding Lignin Aggregation Processes. A Case Study: Budesonide Entrapment and Stimuli Controlled Release from Lignin Nanoparticles|
|Rivista:||ACS SUSTAINABLE CHEMISTRY & ENGINEERING|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1021/acssuschemeng.8b01652|
|Appare nelle tipologie:||2.1 Articolo su rivista |