Herein we present the synthesis of b-mono and b-bis-substituted vinylidenebisphosphonate esters bearing a carboxylic ester moiety to be used as building blocks for further functionalizations. Reactions of these new bisphosphonate scaffolds through hydrogenation of the unsaturated CQC bond and through metal mediated addition of aryl boronic acids and indoles provide a wide range of new bisphosphonate products as potential leads to contrast osteoporosis.
Functional bisphosphonate synthesis for the development of new anti-resorption bone drug candidates
Enrica BortolamiolMembro del Collaboration Group
;Andrea ChiminazzoMembro del Collaboration Group
;Laura SperniMembro del Collaboration Group
;Giuseppe BorsatoMembro del Collaboration Group
;Fabrizio FabrisProject Administration
;Alessandro Scarso
Project Administration
2019-01-01
Abstract
Herein we present the synthesis of b-mono and b-bis-substituted vinylidenebisphosphonate esters bearing a carboxylic ester moiety to be used as building blocks for further functionalizations. Reactions of these new bisphosphonate scaffolds through hydrogenation of the unsaturated CQC bond and through metal mediated addition of aryl boronic acids and indoles provide a wide range of new bisphosphonate products as potential leads to contrast osteoporosis.File in questo prodotto:
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