3-Chloronorbornenone (R)-1a (98% ee) was obtained from trichloronorbornene 5 in two steps by the in situ generation of dichloronorbornadiene 2a with t-BuOK and desymmetrization with (-)-ephedrine, followed by hydrolysis with PPTS. The generality of this desymmetrization with (-)- ephedrine was tested with dibromonorbornadiene 2c and other substituted dichloronorbornadienes.
Autori: | |
Data di pubblicazione: | 2007 |
Titolo: | Chiral Polycyclic Ketones via Desymmetrization of Dihaloolefins |
Rivista: | JOURNAL OF ORGANIC CHEMISTRY |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1021/jo070222g |
Volume: | 72 |
Appare nelle tipologie: | 2.1 Articolo su rivista |
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