The synthesis of a conjugate molecule between an unusual red-fluorescent diketopyrrolopyrrole (DPP) unit and a bis-phosphonate (BP) precursor by a click-chemistry strategy to target bone tissue and monitor the interaction is reported. After thorough investigation, conjugation through a triazole unit between a γ-azido rather than a β-azido BP and an alkyne-functionalized DPP fluorophore group turned out to be the winning strategy. Visualization of the DPP-BP conjugate on osteoclasts and specific antiresorption activity were successfully demonstrated.
Autori: | Scarso, Alessandro (Corresponding) |
Data di pubblicazione: | 2019 |
Titolo: | Diketopyrrolopyrrole Bis-Phosphonate Conjugate: A New Fluorescent Probe for In Vitro Bone Imaging |
Rivista: | CHEMISTRY-A EUROPEAN JOURNAL |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/chem.201805436 |
Volume: | 25 |
Appare nelle tipologie: | 2.1 Articolo su rivista |
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2019ChemEurJ.pdf | Documento in Post-print | Accesso chiuso-personale | Open Access dal 26/03/2021 |
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