The synthesis of a conjugate molecule between an unusual red-fluorescent diketopyrrolopyrrole (DPP) unit and a bis-phosphonate (BP) precursor by a click-chemistry strategy to target bone tissue and monitor the interaction is reported. After thorough investigation, conjugation through a triazole unit between a γ-azido rather than a β-azido BP and an alkyne-functionalized DPP fluorophore group turned out to be the winning strategy. Visualization of the DPP-BP conjugate on osteoclasts and specific antiresorption activity were successfully demonstrated.
Scarso, Alessandro (Corresponding)
|Data di pubblicazione:||2019|
|Titolo:||Diketopyrrolopyrrole Bis-Phosphonate Conjugate: A New Fluorescent Probe for In Vitro Bone Imaging|
|Rivista:||CHEMISTRY-A EUROPEAN JOURNAL|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/chem.201805436|
|Appare nelle tipologie:||2.1 Articolo su rivista |