Herein we present the synthesis of b-mono and b-bis-substituted vinylidenebisphosphonate esters bearing a carboxylic ester moiety to be used as building blocks for further functionalizations. Reactions of these new bisphosphonate scaffolds through hydrogenation of the unsaturated CQC bond and through metal mediated addition of aryl boronic acids and indoles provide a wide range of new bisphosphonate products as potential leads to contrast osteoporosis.
Autori: | |
Data di pubblicazione: | 2019 |
Titolo: | Functional bisphosphonate synthesis for the development of new anti-resorption bone drug candidates |
Rivista: | NEW JOURNAL OF CHEMISTRY |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1039/c9nj02504a |
Volume: | 43 |
Appare nelle tipologie: | 2.1 Articolo su rivista |
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2019NJC.pdf | Documento in Post-print | Accesso gratuito (solo visione) | Open Access dal 10/10/2021 |
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